Attention for Protagonist now turns to PN-943, an oral integrin antagonist, on which mid-stage results are not due until next year at the earliest. But it is clear that investors believe rusfertide, a hepcidin mimetic, to be dead after La Jolla effectively abandoned work on its synthetic hepcidin a couple of years ago, this appears to be an avenue of research now closed. The sellside came to the company’s defence, pointing out examples of other drugs that had showed similar preclinical cancer signals in the same mouse model but which went on to reach the market. The cancer cases had been previously assessed as unrelated to rusfertide, and it is true that the project’s lead indication, the myeloproliferative disorder polycythemia vera, can, rarely, progress to cancer. The company disclosed that four cases of cancer had been seen across clinical trials of rusfertide the earlier press release only referenced findings in mouse models. Our custom made binary options system gets the quotes from the worldwide finance market and makes technical analysis of the asset’s prices in an automatic way. Read the Entire Report in Just 30 Minutes. Discover the specific indicators that generated winning trades 82of the time and outperformed the market by 2,602 on average.

Optionalpha - Option Alpha Signals (Technical Analysis) We Backtested More Than 17.34 Million Stock Trades Over 20 Yearsto See What Really Works. Further detail, inexplicably released after markets closed in an SEC filing, only add to concerns. Course, Trading, Technical Analysis, Optionalpha, Option Alpha Signals. Protagonist's admission that a cancer signal had prompted the FDA to halt trials of rusfertide, or PTG-300, caused its shares to slump 62% on Friday, erasing $1.4bn from the biotech’s market cap.

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